Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448200 | 0.85 | KDM4E (0.67) | KDM4ESMN1; SMN2PKMKMT2AALDH1A1 | |
| SCHEMBL3448205 | 0.85 | KDM4E (0.67) | KDM4ESMN1; SMN2PKMKMT2AALDH1A1 | |
| SCHEMBL4592027 | 0.84 | KMT2A (0.54) | KDM4ESMN1; SMN2PKMKMT2AALDH1A1 | |
| SCHEMBL14720130 | 0.84 | CHIT1 (0.52) | KDM4EPKMKMT2AALDH1A1 | |
| SCHEMBL12426363 | 0.82 | HTR4 (0.66) | ALDH1A1TDP1POLBGAA | |
| SCHEMBL11760297 | 0.81 | SMN1; SMN2 (0.64) | HPGDSMN1; SMN2L3MBTL1PKMKMT2A | |
| SCHEMBL11757383 | 0.81 | SMN1; SMN2 (0.64) | HPGDSMN1; SMN2L3MBTL1PKMKMT2A | |
| SCHEMBL27304810 | 0.80 | NPC1 (0.52) | HPGDSMN1; SMN2L3MBTL1PKMKMT2A | |
| SCHEMBL4396197 | 0.78 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2L3MBTL1PKMKMT2A | |
| SCHEMBL483635 | 0.77 | CXCR3 (0.58) | HPGDKDM4ESMN1; SMN2L3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |