Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592805 | 1.00 | HPGD (0.52) | HPGDSMN1; SMN2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL3447693 | 0.83 | KDM4E (0.57) | HPGDALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL3447689 | 0.83 | KDM4E (0.57) | HPGDALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL14720130 | 0.80 | CHIT1 (0.52) | ALDH1A1LMNAKMT2A | |
| SCHEMBL4592841 | 0.78 | GAA (0.49) | HPGDALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4592027 | 0.74 | KMT2A (0.54) | SMN1; SMN2ALDH1A1LMNAKMT2ATSHR | |
| SCHEMBL14720615 | 0.74 | DRD2 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL4592410 | 0.74 | NPC1 (0.49) | L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL4592619 | 0.73 | ACKR3 (0.39) | MEN1KMT2ANPSR1 | |
| SCHEMBL1750661 | 0.73 | RAB9A (0.65) | HPGDSMN1; SMN2ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |