Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10083028 | 1.00 | ROCK2 (0.40) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL433687 | 0.88 | TRPV1 (0.40) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL15385522 | 0.88 | TRPV1 (0.40) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL459835 | 0.87 | ROCK2 (0.39) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL459836 | 0.87 | ROCK2 (0.39) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL434875 | 0.86 | TRPV1 (0.42) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL15385515 | 0.86 | TRPV1 (0.42) | ROCK2ROCK1AURKAAURKBCDC7 | |
| SCHEMBL435831 | 0.83 | HSD11B1 (0.50) | GPR88MAPK1MITFALDH1A1HTT | |
| SCHEMBL15385492 | 0.83 | HSD11B1 (0.50) | GPR88MAPK1MITFALDH1A1HTT | |
| SCHEMBL433254 | 0.82 | MAPK1 (0.42) | ROCK2ROCK1AURKAAURKBCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |