SCHEMBL459361

SCHEMBL459361

CON=C(COc1ccc(COc2cc(F)c(CCC(=O)O)cc2F)cc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 15/20 0.57
RXRG P48443 2/20 0.45
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
FFAR4 Q5NUL3 7/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL459360 1.00 FFAR1 (0.57) FFAR1RXRGRXRARXRBFFAR4
SCHEMBL433652 0.90 FFAR1 (0.51) FFAR1RXRGRXRARXRBFFAR4
SCHEMBL433653 0.90 FFAR1 (0.51) FFAR1RXRGRXRARXRBFFAR4
SCHEMBL434058 0.90 FFAR1 (0.61) FFAR1FFAR4
SCHEMBL434057 0.90 FFAR1 (0.61) FFAR1FFAR4
SCHEMBL22668364 0.88 FFAR1 (0.51) FFAR1
SCHEMBL22668348 0.85 FFAR1 (0.47) FFAR1RXRGRXRARXRBFFAR4
SCHEMBL433326 0.85 FFAR1 (0.62) FFAR1FFAR4
SCHEMBL433325 0.85 FFAR1 (0.62) FFAR1FFAR4
SCHEMBL434213 0.83 FFAR1 (0.58) FFAR1RXRGFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237571-A1 AGONISTS OF GPR40 GPR65, GPR55, GPR68 FFAR1 24/4885RXRG 254/4885RXRA 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.