Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187850 | 0.91 | ALDH1A1 (0.56) | ALDH1A1TDP1KMT2AGAAHTT | |
| Hydrochloric Acid SCHEMBL3601018 | 0.89 | ALDH1A1 (0.55) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL220634 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL31693329 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL7914237 | 0.85 | ALDH1A1 (0.49) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL2241497 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL3488943 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KMT2AGAAHTTMAPK1 | |
| SCHEMBL6117681 | 0.73 | PDK1 (0.47) | ALDH1A1TDP1KMT2AGAAHTT | |
| SCHEMBL19172441 | 0.73 | NPC1 (0.50) | ALDH1A1KMT2AGAAHTTMAPK1 | |
| SCHEMBL28797610 | 0.73 | MAPT (0.47) | ALDH1A1KMT2AGAAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948667-A2 | THIAZOLO[4,5-C]PYRIDINE DERIVATIVES AS MGLU5 RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054436-A2 | THIAZOLO [4 , 5-C] PYRIDINE DERIVATIVES AS MGLU5 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-18 | — | — | WO | disclosed |