Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 4/20 | 0.32 |
| ▸ | PPARD | Q03181 | 4/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459455 | 0.80 | GPR119 (0.33) | GPR119ACACBSMO | |
| SCHEMBL16187538 | 0.76 | NFE2L2 (0.42) | ACACB | |
| SCHEMBL9925927 | 0.74 | MAPT (0.47) | GPR119 | |
| SCHEMBL462366 | 0.71 | ALOX5AP (0.37) | GPR119ACACBPPARGPPARDPPARA | |
| SCHEMBL8513708 | 0.70 | SMO (0.42) | GPR119PTPN11SMO | |
| SCHEMBL11919298 | 0.70 | CKS1B (0.49) | GPR119PTPN11 | |
| SCHEMBL121187 | 0.70 | GPR119 (0.49) | GPR119ACACB | |
| SCHEMBL12989025 | 0.69 | ACHE (0.38) | GPR119 | |
| SCHEMBL5884674 | 0.69 | GPR119 (0.38) | GPR119ACACBPTPN11 | |
| SCHEMBL457426 | 0.68 | GPR119 (0.62) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |