SCHEMBL4594579

SCHEMBL4594579

Cc1ccc(C)n1-c1cc(COS(C)(=O)=O)ccn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKT1 P31749 1/20 0.36
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
PTGER1 P34995 6/20 0.34
FFAR1 O14842 1/20 0.33
GRM5 P41594 2/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
ADAMTS4 O75173 1/20 0.31
MMP13 P45452 1/20 0.31
MAPK14 Q16539 1/20 0.31
TLR7 Q9NYK1 1/20 0.31
HRH3 Q9Y5N1 1/20 0.30
KDM5A P29375 1/20 0.30
KDM4C Q9H3R0 1/20 0.30
PLA2G10 O15496 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL615622 0.79 KCNQ2 (0.43) AKT1ALDH1A1FFAR1GRM5CA1
SCHEMBL4594365 0.77 ALDH1A1 (0.34) ALDH1A1LMNA
SCHEMBL29962624 0.74 LOXL2 (0.49) AKT1FFAR1CA2CA9CYP3A4
SCHEMBL501336 0.74 LOXL2 (0.49) AKT1FFAR1CA2CA9CYP3A4
SCHEMBL1670067 0.74 PARP1 (0.35) AKT1CA1CA2CA9CYP1A2
SCHEMBL3116042 0.74 CYP1A2 (0.39) AKT1CA1CA2CA9CYP1A2
SCHEMBL5793683 0.74 RECQL (0.49) AKT1LMNAFFAR1GRM5CA1
SCHEMBL18585998 0.73 ALDH1A1 (0.36) ALDH1A1LMNAKDM5AKDM4C
SCHEMBL4593796 0.73 RECQL (0.47) ALDH1A1LMNAHRH3KDM5AKDM4C
SCHEMBL29995296 0.73 LOX (0.56) LMNAFFAR1CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1891047-A4 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE AG (DE) 2008-07-09 EP disclosed
EP-1891047-A2 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS Bayer HealthCare AG (DE) 2008-02-27 EP disclosed
WO-2006133006-A2 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE AG (DE) 2006-12-14 WO disclosed