Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.30 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596652 | 0.97 | KIF11 (0.40) | KIF11TRPV1BRD4BRD2CREBBP | |
| SCHEMBL4596019 | 0.72 | KIF11 (0.44) | KIF11RORCPDE3BPDE3A | |
| SCHEMBL4596493 | 0.71 | NOTUM (0.47) | KIF11PDE3BPDE3A | |
| SCHEMBL4596143 | 0.69 | KIF11 (0.66) | KIF11PDE3BPDE3ATDP2 | |
| SCHEMBL4898840 | 0.69 | CYP11B1 (0.53) | KIF11PDE3BPDE3A | |
| SCHEMBL4596440 | 0.68 | KIF11 (0.63) | KIF11TRPV1BRD4BRD2CREBBP | |
| SCHEMBL4596362 | 0.67 | KIF11 (0.61) | KIF11PDE3BPDE3ATDP2 | |
| SCHEMBL4897709 | 0.66 | CYP1A2 (0.55) | KIF11TRPV1TDP2 | |
| SCHEMBL4890586 | 0.65 | KIF11 (0.58) | KIF11PDE3BPDE3A | |
| SCHEMBL4891714 | 0.62 | KIF11 (0.49) | KIF11PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |