Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594863 | 0.97 | KIF11 (0.39) | KIF11TRPV1BRD4BRD2CREBBP | |
| SCHEMBL4898840 | 0.72 | CYP11B1 (0.53) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL4596440 | 0.71 | KIF11 (0.63) | KIF11TRPV1BRD4BRD2CREBBP | |
| SCHEMBL4596362 | 0.70 | KIF11 (0.61) | KIF11PDE3BPDE3ATDP2CYP11B1 | |
| SCHEMBL4897709 | 0.69 | CYP1A2 (0.55) | KIF11TRPV1TDP2CYP11B1CYP11B2 | |
| SCHEMBL4596019 | 0.68 | KIF11 (0.44) | KIF11RORCPDE3BPDE3A | |
| SCHEMBL4890586 | 0.66 | KIF11 (0.58) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL4596493 | 0.64 | NOTUM (0.47) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL27394981 | 0.63 | BRD4 (0.62) | KIF11TRPV1BRD4BRD2CREBBP | |
| SCHEMBL22340014 | 0.63 | BRD4 (0.56) | KIF11BRD4BRD2CREBBPPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |