SCHEMBL4593487

SCHEMBL4593487

COC(=O)c1ccc2sc(N(Cc3cc(OC(C)C)cc(OC(C)C)c3)C3CCNCC3)nc2c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 2/20 0.38
MBTPS1 Q14703 3/20 0.37
IDH1 O75874 1/20 0.36
LIPG Q9Y5X9 1/20 0.35
HTR2A P28223 1/20 0.35
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
HSP90AA1 P07900 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34
THRB P10828 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
ROCK2 O75116 1/20 0.33
SLC6A9 P48067 1/20 0.33
SLC6A5 Q9Y345 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4594515 0.92 NPC1 (0.39) TRPV1MBTPS1IDH1HTR2ANPC1
SCHEMBL4594509 0.85 NPC1 (0.44) MBTPS1HTR2ANPC1RAB9ATP53
SCHEMBL4594161 0.85 NFKB1 (0.38) MBTPS1HTR2ANPC1RAB9ASLC6A2
SCHEMBL4594394 0.82 SSTR1 (0.39) LIPGNPC1RAB9AHSP90AA1TP53
SCHEMBL4593462 0.82 RAB9A (0.40) MBTPS1IDH1HTR2ANPC1RAB9A
SCHEMBL4594611 0.80 TP53 (0.38) MBTPS1IDH1HTR2ANPC1RAB9A
SCHEMBL4594897 0.80 HTR2A (0.34) MBTPS1HTR2ASLC6A2SLC6A4SLC6A3
SCHEMBL4593786 0.79 SSTR5 (0.35) NPC1RAB9AHSP90AA1SLC6A2SLC6A4
SCHEMBL4593776 0.78 SSTR5 (0.40) HDAC6
SCHEMBL4703127 0.76 SLC6A2 (0.44) MBTPS1HTR2ASLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924579-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2008-05-28 EP claimed
WO-2007025897-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-03-08 WO claimed
EP-1924579-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2008-05-28 EP disclosed
WO-2007025897-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-03-08 WO disclosed