Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896788 | 0.84 | CA9 (0.45) | KIF11TDP2CA9CA12 | |
| SCHEMBL4596154 | 0.83 | KIF11 (0.41) | KIF11TDP2CA9CA12AKT1 | |
| SCHEMBL4596437 | 0.83 | KIF11 (0.65) | KIF11CYP11B1CYP11B2TDP2PDE3B | |
| SCHEMBL15966047 | 0.74 | METAP2 (0.36) | KIF11CA9CA12 | |
| SCHEMBL4889182 | 0.71 | KIF11 (0.70) | KIF11CYP11B1CYP11B2TDP2PDE3B | |
| SCHEMBL4596526 | 0.69 | KIF11 (0.57) | KIF11CYP11B1CYP11B2TDP2PDE3B | |
| SCHEMBL4596034 | 0.68 | KIF11 (0.52) | KIF11TDP2CA9CA12 | |
| SCHEMBL4898372 | 0.68 | KIF11 (0.72) | KIF11CYP11B1CYP11B2TDP2PDE3B | |
| SCHEMBL1903306 | 0.67 | KIF11 (0.80) | KIF11CYP11B1CYP11B2TDP2PDE3B | |
| SCHEMBL4897633 | 0.66 | KIF11 (0.57) | KIF11TDP2PDE3BPDE3ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |