Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896788 | 0.86 | CA9 (0.45) | KIF11CA9CA12TDP2 | |
| SCHEMBL4596034 | 0.86 | KIF11 (0.52) | KIF11CA9CA12TDP2CHRNB2 | |
| SCHEMBL4595237 | 0.83 | KIF11 (0.47) | KIF11CA9CA12TDP2AKT1 | |
| SCHEMBL15966047 | 0.76 | METAP2 (0.36) | KIF11CA9CA12 | |
| SCHEMBL4898485 | 0.67 | KIF11 (0.59) | KIF11CA9CA12TDP2AKT1 | |
| SCHEMBL6911317 | 0.66 | CYP11B2 (0.42) | — | |
| SCHEMBL6910702 | 0.65 | CYP11B1 (0.60) | TDP2 | |
| SCHEMBL4596437 | 0.62 | KIF11 (0.65) | KIF11TDP2AKT1CDK2CDK1 | |
| SCHEMBL4897633 | 0.62 | KIF11 (0.57) | KIF11CA9CA12TDP2AKT1 | |
| SCHEMBL28061563 | 0.62 | KIF11 (0.46) | KIF11CA9CA12TDP2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |