Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.62 |
| ▸ | GRM5 | P41594 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6076987 | 0.81 | NPC1 (0.62) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL6076991 | 0.81 | NPC1 (0.62) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL28612858 | 0.79 | CYP1A2 (0.34) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL28605730 | 0.78 | CHRM5 (0.64) | NPC1RAB9ACYP1A2CYP2D6CHRM5 | |
| SCHEMBL28618284 | 0.78 | ALDH1A1 (0.50) | PKMCYP1A2CYP2D6CHRM5PTGS1 | |
| SCHEMBL12017614 | 0.77 | NPC1 (1.00) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL29392337 | 0.77 | NPC1 (1.00) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL12497017 | 0.77 | NPC1 (1.00) | NPC1RAB9APKMCYP1A2CYP3A4 | |
| SCHEMBL11099642 | 0.77 | RECQL (0.51) | NPC1RAB9APKMNFE2L2MAOB | |
| SCHEMBL11099640 | 0.77 | RECQL (0.51) | NPC1RAB9APKMNFE2L2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937674-A1 | ISOXAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| US-7378435-B2 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-27 | — | — | US | disclosed |
| WO-2007042420-A1 | ISOXAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082936-A1 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | HOFFMANN-LA ROCHE INC. | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082936-A1 | Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives | GABRA5, GABRA4, CHRNA5 | NPC1 1358/4885RAB9A 1381/4885PKM 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.