SCHEMBL4595414

SCHEMBL4595414

CC(=O)OOc1ccc(C)cc1C#N

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
AR P10275 6/20 0.40
IMPDH2 P12268 1/20 0.40
FFAR1 O14842 1/20 0.40
XDH P47989 2/20 0.38
F11 P03951 1/20 0.38
MAOB P27338 1/20 0.38
HPGD P15428 2/20 0.37
KDM4E B2RXH2 2/20 0.37
USP2 O75604 1/20 0.37
NPC1 O15118 1/20 0.36
TP53 P04637 1/20 0.36
RAB9A P51151 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HCRTR1 O43613 1/20 0.36
HCRTR2 O43614 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4595417 0.83 MAOB (0.48) ALDH1A1ARIMPDH2FFAR1XDH
SCHEMBL4324068 0.83 ALDH1A1 (0.58) ALDH1A1ARF11MAOBHPGD
SCHEMBL5271103 0.83 AAK1 (0.43) ALDH1A1XDHMAOBHPGDKDM4E
SCHEMBL4595012 0.79 PTPN1 (0.45) ALDH1A1ARHPGDKDM4EUSP2
SCHEMBL5970515 0.78 SMN1; SMN2 (0.47) ALDH1A1HPGDKDM4ENPC1TP53
SCHEMBL3375489 0.77 MAOB (0.45) ALDH1A1ARIMPDH2FFAR1MAOB
SCHEMBL9034189 0.76 AR (0.43) ALDH1A1ARIMPDH2FFAR1XDH
SCHEMBL27699733 0.75 MRGPRX4 (0.43) ALDH1A1HPGDKDM4EUSP2NPC1
SCHEMBL5263671 0.74 SSTR4 (0.40) ALDH1A1IMPDH2MAOBHPGDKDM4E
SCHEMBL1003862 0.74 ALDH1A1 (0.46) ALDH1A1ARFFAR1MAOBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945646-A1 PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS Cellzome (UK) Ltd. (GB) 2008-07-23 EP disclosed
WO-2007039467-A1 PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS CELLZOME (UK) LTD. (GB) 2007-04-12 WO disclosed