SCHEMBL459546

SCHEMBL459546

Cc1n[nH]c(C(=N)N)c1C

nearest known ligand 0.42

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14184934 0.70 DYRK1A (0.44) DYRK1A
SCHEMBL15824828 0.70 DYRK1A (0.44) DYRK1A
SCHEMBL23979359 0.68 DYRK1A (0.42) DYRK1A
SCHEMBL6195861 0.68 PDE4D (0.47) DYRK1A
Hydrochloric Acid SCHEMBL9079591 0.67 PDE4D (0.46) DYRK1A
SCHEMBL7902863 0.65 KDM4C (0.53) DYRK1A
SCHEMBL6827922 0.64
SCHEMBL8723377 0.64 DYRK1A (0.42) DYRK1A
SCHEMBL6336859 0.62 PDPK1 (0.41) DYRK1A
SCHEMBL15871865 0.62 UMPS (0.40) DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614046-A1 NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES Produits Chimiques Auxiliaires et de Synthese (FR) 2013-07-17 EP disclosed
WO-2012032257-A1 NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) 2012-03-15 WO disclosed
EP-1324983-A1 PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES Pharmacia Italia S.p.A. (IT) 2003-07-09 EP disclosed
WO-2002002523-A1 PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES PHARMACIA ITALIA S.P.A. (IT) 2002-01-10 WO disclosed