Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225698 | 0.85 | AQP1 (0.54) | AQP1SIRT2EZH2SSTR2SSTR4 | |
| SCHEMBL4596679 | 0.84 | SIRT2 (0.50) | AQP1SIRT2CYP3A4SSTR2SSTR4 | |
| SCHEMBL4596108 | 0.84 | AQP1 (0.51) | AQP1SIRT2CYP3A4EZH2DRD4 | |
| SCHEMBL4596497 | 0.84 | SIRT2 (0.56) | AQP1SIRT2CYP3A4EZH2SSTR2 | |
| SCHEMBL4220310 | 0.82 | AQP1 (0.56) | AQP1SIRT2EZH2SSTR2SSTR4 | |
| SCHEMBL4596351 | 0.80 | AQP1 (0.45) | AQP1 | |
| SCHEMBL4595085 | 0.80 | SIRT2 (0.54) | AQP1SIRT2CYP3A4EZH2SSTR2 | |
| SCHEMBL4225690 | 0.80 | AQP1 (0.77) | AQP1SIRT2CYP3A4EZH2SLC6A2 | |
| SCHEMBL4232694 | 0.79 | AQP1 (0.58) | AQP1SIRT2CYP3A4EZH2 | |
| SCHEMBL4595481 | 0.79 | AQP1 (0.43) | AQP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |