Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23855055 | 0.81 | TGFBR1 (0.36) | MMEFOLH1NAALAD2ALDH1A1MMP1 | |
| SCHEMBL394954 | 0.81 | TGFBR1 (0.36) | MMEFOLH1NAALAD2ALDH1A1MMP1 | |
| SCHEMBL1069360 | 0.81 | OR51E2 (0.33) | MMEMMP1TGFBR1LMNA | |
| SCHEMBL3910231 | 0.78 | LAP3 (0.41) | FOLH1NAALAD2ALDH1A1MEN1LMNA | |
| SCHEMBL15270313 | 0.75 | TRPA1 (0.36) | MMEFOLH1NAALAD2ALDH1A1TRPA1 | |
| SCHEMBL1132971 | 0.74 | MEN1 (0.31) | CA2TGFBR1MEN1KMT2A | |
| SCHEMBL15872915 | 0.74 | TRPA1 (0.39) | MMEFOLH1NAALAD2ALDH1A1TRPA1 | |
| SCHEMBL16515196 | 0.74 | TRPA1 (0.39) | MMEFOLH1NAALAD2ALDH1A1TRPA1 | |
| SCHEMBL16515197 | 0.74 | TRPA1 (0.39) | MMEFOLH1NAALAD2ALDH1A1TRPA1 | |
| SCHEMBL3914911 | 0.72 | SLC1A2 (0.37) | ALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |