Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.37 |
| ▸ | AQP1 | P29972 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596523 | 0.88 | HTR1A (0.43) | HTR1ACNR1CNR2PARP1BRD4 | |
| SCHEMBL6047916 | 0.87 | HTR1A (0.42) | HTR1ACNR1CNR2PARP1GRM2 | |
| SCHEMBL4596281 | 0.82 | GABRA1 (0.34) | HTR1ACNR1CNR2GRM2AQP1 | |
| SCHEMBL4596981 | 0.81 | PARP1 (0.48) | HTR1ACNR1CNR2PARP1GRM2 | |
| SCHEMBL4649844 | 0.81 | PARP1 (0.48) | HTR1ACNR1CNR2PARP1GRM2 | |
| SCHEMBL4230244 | 0.78 | AQP1 (0.42) | CNR2GRM2AQP1MAOBGABRA1 | |
| SCHEMBL4964386 | 0.78 | AQP1 (0.42) | GRM2AQP1GABRA1GABRG2GABRB3 | |
| SCHEMBL4230148 | 0.78 | AQP1 (0.46) | GRM2AQP1MAOBGABRA1GABRG2 | |
| SCHEMBL4229956 | 0.78 | AQP1 (0.62) | GRM2AQP1 | |
| SCHEMBL4710394 | 0.77 | CNR1 (0.38) | HTR1ACNR1CNR2PARP1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |