Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596981 | 0.87 | PARP1 (0.48) | PARP1HTR1AHTR7CNR1CNR2 | |
| SCHEMBL4595292 | 0.85 | AQP1 (0.44) | PARP1HTR1AHTR7CNR1CNR2 | |
| SCHEMBL4712948 | 0.85 | BRD4 (0.44) | PARP1HTR1ACNR1CNR2BRD4 | |
| SCHEMBL6047940 | 0.82 | PARP1 (0.49) | PARP1HTR1ABRD4CREBBPMAOA | |
| SCHEMBL4710394 | 0.82 | CNR1 (0.38) | PARP1HTR1AHTR7CNR1CNR2 | |
| SCHEMBL4595495 | 0.81 | PARP1 (0.46) | PARP1HTR1AHTR7CNR1CNR2 | |
| SCHEMBL4596283 | 0.81 | HTR1A (0.44) | PARP1HTR1ACNR1CNR2BRD4 | |
| SCHEMBL4765146 | 0.81 | AQP1 (0.50) | PARP1HTR1AHTR7CNR1CNR2 | |
| SCHEMBL4649843 | 0.81 | HTR1A (0.40) | HTR1AHTR7GRM2HTR2AHTR2C | |
| SCHEMBL5583714 | 0.80 | CNR1 (0.39) | PARP1HTR1AHTR7CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |