Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | AQP1 | P29972 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595340 | 0.93 | SIRT2 (0.36) | SIRT2AQP1LPAR1LPAR5MEN1 | |
| SCHEMBL4596631 | 0.85 | AQP1 (0.57) | SIRT2AQP1LPAR1LPAR5MEN1 | |
| SCHEMBL6368238 | 0.84 | AQP1 (0.47) | SIRT2AQP1MEN1KMT2AALDH1A1 | |
| SCHEMBL4596674 | 0.83 | SIRT2 (0.39) | SIRT2AQP1LPAR1LPAR5MEN1 | |
| SCHEMBL4225416 | 0.82 | MEN1 (0.37) | SIRT2AQP1MEN1KMT2ATMEM97 | |
| SCHEMBL4596313 | 0.82 | S1PR2 (0.38) | AQP1LPAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4220872 | 0.81 | AQP1 (0.42) | SIRT2AQP1MEN1KMT2ACNR2 | |
| SCHEMBL4596601 | 0.80 | MEN1 (0.36) | SIRT2AQP1MEN1KMT2AALDH1A1 | |
| SCHEMBL4229920 | 0.80 | AQP1 (0.45) | SIRT2AQP1LPAR1LPAR5MEN1 | |
| SCHEMBL5002222 | 0.80 | OXTR (0.42) | SIRT2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |