Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596542 | 0.88 | CA1 (0.45) | CA1CA2ACHECYP2C19POLB | |
| SCHEMBL5186083 | 0.86 | GAA (0.40) | SMN1; SMN2CA1CA2ACHEMGAM | |
| SCHEMBL5186091 | 0.85 | MEN1 (0.43) | SMN1; SMN2CA1CA2ACHEMGAM | |
| SCHEMBL5653055 | 0.76 | CA1 (0.46) | CA1CA2ACHECYP2C19GAA | |
| SCHEMBL6255859 | 0.75 | CYP2C19 (0.49) | SMN1; SMN2NR3C1FFAR1FFAR4CYP3A4 | |
| SCHEMBL5186024 | 0.74 | HTR1A (0.33) | SMN1; SMN2MGAMGAASIMGAM2 | |
| SCHEMBL18908296 | 0.73 | ALDH1A1 (0.39) | SMN1; SMN2NR3C1FFAR1FFAR4CA1 | |
| SCHEMBL18908273 | 0.73 | ALDH1A1 (0.39) | SMN1; SMN2NR3C1FFAR1FFAR4CA1 | |
| SCHEMBL2588953 | 0.72 | ADRA2A (0.45) | HTR2AHTR2CADRA1A | |
| SCHEMBL2592419 | 0.72 | ADRA2A (0.45) | HTR2AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1802598-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2006047288-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | WYETH (US) | 2006-05-04 | — | — | WO | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |