Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596788 | 0.83 | DRD2 (0.52) | PARP1HTR1ADRD2HTR7BRD4 | |
| SCHEMBL4596908 | 0.82 | DRD2 (0.37) | PARP1MAOAMAOBDRD2HTR7 | |
| SCHEMBL4596758 | 0.82 | MAOA (0.43) | PARP1HTR1AMAOAMAOBBRD4 | |
| SCHEMBL4608434 | 0.81 | PARP1 (0.44) | PARP1HTR1AMAOAMAOBBRD4 | |
| Ammonia Solution, Strong SCHEMBL27703064 | 0.80 | DRD2 (0.53) | PARP1HTR1AMAOAMAOBDRD2 | |
| SCHEMBL4596565 | 0.80 | PARP1 (0.53) | PARP1HTR1AMAOAMAOBDRD2 | |
| SCHEMBL6047940 | 0.80 | PARP1 (0.49) | PARP1HTR1AMAOAMAOBBRD4 | |
| SCHEMBL4597590 | 0.80 | HTR1A (0.46) | PARP1HTR1AMAOAMAOBHTR7 | |
| SCHEMBL5583539 | 0.79 | HPRT1 (0.47) | PARP1HTR1AMAOAMAOBBRD4 | |
| SCHEMBL4625851 | 0.78 | HTR1A (0.47) | PARP1HTR1AHTR7BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |