Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595495 | 0.85 | PARP1 (0.46) | HTR1AHTR7PARP1MAOAMAOB | |
| SCHEMBL4597588 | 0.82 | HTR7 (0.43) | HTR1AHTR7PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4596981 | 0.81 | PARP1 (0.48) | HTR1AHTR7PARP1MAOAMAOB | |
| SCHEMBL4596910 | 0.80 | PARP1 (0.49) | HTR1AHTR7PARP1MAOAMAOB | |
| SCHEMBL4712948 | 0.79 | BRD4 (0.44) | HTR1APARP1MAOAMAOBBRD4 | |
| SCHEMBL4595292 | 0.79 | AQP1 (0.44) | HTR1AHTR7PARP1MAOAMAOB | |
| SCHEMBL4225611 | 0.78 | PRKAB2 (0.62) | HTR1AHTR7MAOBPRKAB2PRKAG1 | |
| SCHEMBL4595480 | 0.78 | PARP1 (0.43) | HTR1APARP1MAOAMAOBPRKAB2 | |
| SCHEMBL4595395 | 0.78 | PARP1 (0.43) | HTR1APARP1MAOAMAOBPRKAB2 | |
| SCHEMBL4649844 | 0.78 | PARP1 (0.48) | HTR1AHTR7PARP1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |