Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595427 | 0.99 | LMNA (0.35) | LMNATSHRNPSR1ALDH1A1KMT2A | |
| SCHEMBL4574346 | 0.98 | HTT (0.34) | LMNATSHRNPSR1ALDH1A1KMT2A | |
| SCHEMBL4575118 | 0.89 | HCRTR1 (0.30) | SPR | |
| SCHEMBL4574395 | 0.89 | HCAR2 (0.35) | ALDH1A1RBP4 | |
| SCHEMBL4597065 | 0.89 | HCRTR1 (0.33) | LMNASMN1; SMN2HPGD | |
| SCHEMBL4573882 | 0.85 | SMN1; SMN2 (0.34) | TSHRALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4574534 | 0.77 | CYP3A4 (0.31) | — | |
| SCHEMBL4574391 | 0.76 | MEN1 (0.30) | KMT2AMEN1 | |
| SCHEMBL4738064 | 0.76 | AVPR1A (0.34) | LMNATSHRNPSR1ALDH1A1KMT2A | |
| SCHEMBL14068675 | 0.75 | ACACB (0.36) | LMNATSHRNPSR1AVPR1ASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071766-A2 | SPIRO-INDENE SUBSTITUTED IMIDAZONAPHYTHYRIDINE AND PYRANOIMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF GASTRIC ACID SECRETION | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |