Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.39 |
| ▸ | AQP1 | P29972 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.31 |
| ▸ | SLC9A2 | Q9UBY0 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596667 | 0.88 | AQP1 (0.43) | GPBAR1AQP1PARP1ALDH1A1MAPK1 | |
| SCHEMBL4236359 | 0.86 | GPBAR1 (0.41) | GPBAR1ALDH1A1MAPK1 | |
| SCHEMBL4231362 | 0.86 | AKR1C3 (0.38) | GPBAR1AQP1PARP1ALDH1A1LMNA | |
| SCHEMBL4596574 | 0.84 | ALDH1A1 (0.40) | PARP1ALDH1A1MAPK1KIF11LMNA | |
| SCHEMBL4231836 | 0.82 | AQP1 (0.42) | GPBAR1AQP1PARP1ALDH1A1MAPK1 | |
| SCHEMBL6047985 | 0.82 | ALDH1A1 (0.34) | GPBAR1ALDH1A1MAPK1KIF11POLB | |
| SCHEMBL4597134 | 0.80 | AQP1 (0.51) | GPBAR1AQP1PARP1ALDH1A1MAPK1 | |
| SCHEMBL4231842 | 0.78 | AQP1 (0.44) | GPBAR1AQP1PARP1ALDH1A1MAPK1 | |
| SCHEMBL4229679 | 0.78 | OXTR (0.42) | GPBAR1AQP1ALDH1A1MAPK1SLC6A9 | |
| SCHEMBL4596236 | 0.77 | MYC (0.39) | PARP1ALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |