Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.60 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | CES1 | P23141 | 2/20 | 0.58 |
| ▸ | CDC25A | P30304 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424141 | 0.83 | ALDH1A1 (0.55) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL5001267 | 0.83 | CHRM5 (0.60) | ALDH1A1ALDH3A1CHRM5CHRM1MAPT | |
| SCHEMBL3025248 | 0.82 | ALDH1A1 (0.64) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL4597041 | 0.82 | ALDH1A1 (0.56) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL5001336 | 0.81 | CHRM5 (0.58) | ALDH1A1ALDH3A1CES1CHRM5CHRM1 | |
| SCHEMBL6283905 | 0.81 | ALDH1A1 (0.62) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL3024396 | 0.81 | CDC25A (0.61) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL3023996 | 0.81 | CES1 (0.61) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL6286569 | 0.80 | CDC25A (0.63) | ALDH1A1ALDH3A1ALDH2CES1CDC25A | |
| SCHEMBL6280422 | 0.80 | CDC25A (0.63) | ALDH1A1ALDH3A1ALDH2CES1CDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | ALDH1A1 1136/4885ALDH3A1 1159/4885ALDH2 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.