Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.64 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.64 |
| ▸ | CES1 | P23141 | 2/20 | 0.62 |
| ▸ | CDC25A | P30304 | 1/20 | 0.62 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16366714 | 0.88 | ALDH1A1 (0.64) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3025055 | 0.87 | CES1 (0.65) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL29011250 | 0.85 | APAF1 (0.53) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL29011256 | 0.84 | APAF1 (0.52) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL29011251 | 0.84 | APAF1 (0.55) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL16046979 | 0.84 | ALDH1A1 (0.62) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL29411355 | 0.83 | APAF1 (0.60) | ALDH1A1ALDH2ALDH3A1CES1APAF1 | |
| SCHEMBL28417285 | 0.81 | CES1 (0.65) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL29220369 | 0.80 | CES1 (0.61) | ALDH1A1ALDH2ALDH3A1CES1APAF1 | |
| SCHEMBL3009244 | 0.80 | ALDH1A1 (0.61) | ALDH1A1ALDH2ALDH3A1CES1CDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046083-A2 | USE OF OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | ALDH1A1 1136/4885ALDH2 720/4885ALDH3A1 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.