Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.61 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | CDC25A | P30304 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.43 |
| ▸ | TUBB | P07437 | 3/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027497 | 0.99 | CES1 (0.62) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3027019 | 0.96 | ALDH1A1 (0.55) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL28710147 | 0.89 | PARK7 (0.64) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3027674 | 0.88 | PARK7 (0.63) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL3023083 | 0.83 | PARK7 (0.53) | ALDH1A1ALDH3A1CES1CHRM5PARK7 | |
| SCHEMBL4597640 | 0.80 | ALDH1A1 (0.64) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL15871530 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14900952 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2A | |
| SCHEMBL28417285 | 0.79 | CES1 (0.65) | ALDH1A1ALDH2ALDH3A1CES1CDC25A | |
| SCHEMBL4022547 | 0.79 | HDAC3 (0.39) | ALDH1A1ALDH2ALDH3A1CES1CDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180200225-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2018-07-19 | — | — | US | disclosed |
| US-20170231953-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CLEVELAND CLINIC FOUND (US) | 2017-08-17 | — | — | US | disclosed |
| US-9656957-B2 | Hydrazone modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2017-05-23 | — | — | US | disclosed |
| US-20150313874-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2015-11-05 | — | — | US | disclosed |
| US-9079854-B2 | Hydrazone modulators of cannabinoid receptors | THE CLEVELAND CLINIC FOUNDATION (US) | 2015-07-14 | — | — | US | disclosed |
| US-20130184275-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2013-07-18 | — | — | US | disclosed |
| US-8309595-B2 | Hydrazone modulators of cannabinoid receptors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-11-13 | — | — | US | disclosed |
| US-20100197755-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-08-05 | — | — | US | disclosed |
| WO-2009012227-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170231953-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2096/4885ALDH2 2253/4885ALDH3A1 1544/4885 |
| US-20150313874-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2096/4885ALDH2 2253/4885ALDH3A1 1544/4885 |
| US-20100197755-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2096/4885ALDH2 2253/4885ALDH3A1 1544/4885 |
| US-20130184275-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2096/4885ALDH2 2253/4885ALDH3A1 1544/4885 |
| US-20180200225-A1 | HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS | CNR1, CNR2, GPR18 | ALDH1A1 2096/4885ALDH2 2253/4885ALDH3A1 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.