Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11491274 | 0.86 | ATM (0.60) | ATMRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL1461981 | 0.86 | ATM (0.60) | ATMRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL5500456 | 0.83 | MMEL1 (0.48) | EPHX2RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL5500451 | 0.79 | CTSL (0.50) | EPHX2MMEL1 | |
| SCHEMBL1553456 | 0.78 | FOLH1 (0.51) | ATMRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL3644580 | 0.78 | L3MBTL1 (0.52) | ATMRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL7457166 | 0.78 | EPHX2 (0.43) | EPHX2RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL5576749 | 0.77 | S1PR3 (0.55) | ATMKEAP1NFE2L2CTSK | |
| SCHEMBL30370359 | 0.77 | S1PR3 (0.55) | ATMKEAP1NFE2L2CTSK | |
| SCHEMBL219211 | 0.77 | S1PR3 (0.55) | ATMKEAP1NFE2L2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |