Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023399 | 0.88 | CCR5 (0.43) | — | |
| SCHEMBL5575420 | 0.85 | GPR119 (0.48) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3754554 | 0.85 | GPR119 (0.48) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4206072 | 0.76 | ATM (0.42) | KDM4EALDH1A1TSHR | |
| SCHEMBL18539369 | 0.75 | KDM4E (0.43) | KDM4EAURKARPS6KB1 | |
| SCHEMBL4609867 | 0.74 | C3AR1 (0.42) | CYP3A4CYP2C19KDM4EDRD3TSHR | |
| SCHEMBL5576515 | 0.73 | EPHX1 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL8311276 | 0.73 | SOS1 (0.58) | KDM4EMEN1KMT2ADRD2DRD4 | |
| SCHEMBL3763458 | 0.72 | CTSK (0.44) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15520799 | 0.71 | GAA (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |