SCHEMBL4597787

SCHEMBL4597787

CCOC(=O)c1c(-c2ccccc2)c2c(c3ccccc13)OC(c1ccccc1)(c1ccccc1)C=C2

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.48
LMNA P02545 3/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
MAPT P10636 6/20 0.46
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 5/20 0.45
HPGD P15428 4/20 0.45
GAA P10253 4/20 0.45
NPSR1 Q6W5P4 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
GRM6 O15303 2/20 0.44
TDP1 Q9NUW8 1/20 0.42
CSF1R P07333 1/20 0.41
TP53 P04637 1/20 0.40
TSHR P16473 1/20 0.39
MAPK10 P53779 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30094410 1.00 SMN1; SMN2 (0.48) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL4597629 0.88 ALDH1A1 (0.43) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL29565457 0.88 ALDH1A1 (0.43) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL4596761 0.86 MEN1 (0.40) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL4598124 0.81 ALDH1A1 (0.49) SMN1; SMN2MEN1KMT2AKDM4EALDH1A1
SCHEMBL5646123 0.81 MAP3K5 (0.41) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL23169694 0.80 MEN1 (0.36) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL23169688 0.80 MEN1 (0.36) SMN1; SMN2LMNAMEN1KMT2AMAPT
SCHEMBL6931279 0.80 SMN1; SMN2 (0.46) SMN1; SMN2LMNAMEN1KMT2AKDM4E
SCHEMBL7596981 0.79 TP53 (0.41) SMN1; SMN2LMNAMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US claimed
EP-4313567-B1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC (CH) 2025-01-29 EP claimed
US-12111443-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-10-08 US claimed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US claimed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP claimed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP claimed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US claimed
CN-115605529-A Photochromic polydiorganosiloxane ethylene crosslinkers 爱尔康公司(CH) 2023-01-13 CN claimed
WO-2022208450-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-10-06 WO claimed
WO-2022189940-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO claimed
WO-2022189941-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO claimed
US-20220281193-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
US-20220283338-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US claimed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US claimed
US-20070159594-A9 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2007-07-12 US claimed
US-20050254003-A1 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2005-11-17 US claimed
US-6353102-B1 FOR OPHTHALMIC LENSES OR CONTACT LENSES PPG INDUSTRIES OHIO, INC. 2002-03-05 US claimed