Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819679 | 0.96 | TAAR1 (0.67) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL4821836 | 0.91 | TAAR1 (0.79) | TAAR1ALDH1A1KMT2AEPHX1GLA | |
| SCHEMBL4597880 | 0.87 | TAAR1 (0.61) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL13743588 | 0.86 | TAAR1 (0.77) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL4819683 | 0.83 | TAAR1 (0.63) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL4598119 | 0.82 | TAAR1 (0.58) | TAAR1ALDH1A1KMT2AGLAHSD17B10 | |
| SCHEMBL3267496 | 0.81 | MC4R (0.62) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL3267405 | 0.81 | MC4R (0.62) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL3923366 | 0.81 | MC4R (0.62) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A | |
| SCHEMBL3267409 | 0.81 | MC4R (0.62) | TAAR1ALDH1A1KMT2AEPHX1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | claimed |
| US-20070032484-A1 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC | 2007-02-08 | — | — | US | claimed |
| EP-1910286-A2 | CATHEPSIN K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-16 | — | — | EP | disclosed |
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-20070032484-A1 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC | 2007-02-08 | — | — | US | disclosed |
| WO-2007014839-A2 | CATHEPSIN K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032484-A1 | Cathepsin K inhibitors | CTSK, CTSS, CTSF | TAAR1 2307/4885ALDH1A1 1616/4885KMT2A 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.