Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598121 | 0.87 | TAAR1 (0.54) | TAAR1F2HTTGLAMC4R | |
| SCHEMBL4821836 | 0.85 | TAAR1 (0.79) | TAAR1F2GLAMC4RSMN1; SMN2 | |
| SCHEMBL4819679 | 0.83 | TAAR1 (0.67) | TAAR1GLAALDH1A1HSD17B10CASP1 | |
| SCHEMBL4597877 | 0.82 | TAAR1 (0.65) | TAAR1F2GLASMN1; SMN2NPC1 | |
| SCHEMBL4825242 | 0.81 | TAAR1 (0.53) | TAAR1F2MC4RSMN1; SMN2RAB9A | |
| SCHEMBL4598774 | 0.81 | EPHX1 (0.56) | TAAR1F2GLASMN1; SMN2RAB9A | |
| SCHEMBL4825547 | 0.77 | TAAR1 (0.49) | TAAR1F2SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4826986 | 0.77 | F2 (0.42) | TAAR1F2 | |
| SCHEMBL4821439 | 0.76 | RAB9A (0.67) | TAAR1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4826832 | 0.74 | SMN1; SMN2 (0.53) | TAAR1F2HTTMC4RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | claimed |
| US-20070032484-A1 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC | 2007-02-08 | — | — | US | claimed |
| EP-1910286-A2 | CATHEPSIN K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-16 | — | — | EP | disclosed |
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-20070032484-A1 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC | 2007-02-08 | — | — | US | disclosed |
| WO-2007014839-A2 | CATHEPSIN K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032484-A1 | Cathepsin K inhibitors | CTSK, CTSS, CTSF | TAAR1 2307/4885F2 2012/4885HTT 1720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.