SCHEMBL459802

SCHEMBL459802

COc1cnc(Cl)nc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6412792 0.77 CYP1A1 (0.55)
SCHEMBL1735138 0.77 PDGFRB (0.49)
SCHEMBL15709858 0.76 ALKBH1 (0.49)
SCHEMBL2599589 0.76 PIN1 (0.55)
SCHEMBL23882512 0.75 KDM4E (0.33)
SCHEMBL3825167 0.74 FTO (0.42)
SCHEMBL7993944 0.74
SCHEMBL160948 0.74 NQO1 (0.48)
SCHEMBL2221457 0.74 PLAU (0.38)
SCHEMBL15709596 0.73 ALDH1A1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 651 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110330461-A A kind of preparation method of 2- chloro-5-methoxyl pyrimidine 苏州莱安医药化学技术有限公司 2019-10-15 CN claimed
CN-110294715-A Synthesis method of 2,4, 6-trichloro-5-methoxypyrimidine 南京普锐达医药科技有限公司 2019-10-01 CN claimed
CN-110106700-A A kind of cellulose base fiber fabric anti-pilling finishing liquid and method for sorting 苏州大学 2019-08-09 CN claimed
CN-110041269-A A kind of preparation method of the chloro- 5- hydroxy pyrimidine of 2- 海门瑞一医药科技有限公司 2019-07-23 CN claimed
CN-102516183-A Method for preparing sulfadoxine and its intermediate CHANGSHU NANHU IND CHEMICAL CO LTD 2012-06-27 CN claimed
CN-102432550-A Preparation method of sulfadoxine and intermediate thereof CHANGSHU NANHU IND CHEMICAL CO LTD 2012-05-02 CN claimed
CN-102304095-A Preparation method of sulfadoxine CHANGSHU NANHU IND CHEMICAL CO LTD 2012-01-04 CN claimed
CN-102304094-A Preparation method of sulfadoxine and intermediate thereof CHANGSHU NANHU IND CHEMICAL CO LTD 2012-01-04 CN claimed
CN-101486684-B Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LTD 2010-11-10 CN claimed
CN-101486684-A Preparation of 2,4-dichloro-5-methoxy pyrimidine CHANGZHOU HUAYI CHEMICAL CO LT (CN) 2009-07-22 CN claimed
US-20260138991-A1 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES MOMA THERAPEUTICS INC (US) 2026-05-21 US disclosed
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-31 US disclosed
EP-4705298-A2 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES Moma Therapeutics, Inc. (US) 2026-03-11 EP disclosed
WO-2026041663-A1 P2X7 RECEPTOR ANTAGONISTS BREYE THERAPEUTICS APS (DK) 2026-02-26 WO disclosed
US-12559508-B2 Semi-saturated bicyclic derivatives and related uses MOMA THERAPEUTICS, INC. (US) 2026-02-24 US disclosed
CN-1111242-A Benzenesulfonamide derivative and process for preparing thereof TANABE SEIYAKU CO (JP) 1995-11-08 CN disclosed
EP-0658548-A1 Benzenesulfonamide derivative and process for preparing thereof TANABE SEIYAKU CO., LTD. (JP) 1995-06-21 EP disclosed
CN-1085556-A The 4-pyrimidyl and the pyridinyl derivatives of the indol-3-yl alkylpiperazine of anti-migraine BRISTOL MYERS SQUIBB CO (US) 1994-04-20 CN disclosed
US-4560689-A ANTICONVULSANTS, ANTIDEPRESSANTS, SEDATIVE ANTIDOTES, AND ANTIEPLILEPTIC AGENTS CIBA-GEIGY CORPORATION (US) 1985-12-24 US disclosed
US-4479955-A ANTICONVULSANTS, ANTIDEPRESSANTS, ANTIEPILEPTIC AGENTS CIBA-GEIGY CORPORATION (US) 1984-10-30 US disclosed