Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.45 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164970 | 0.86 | GLRA1 (0.59) | HSP90AA1HSP90AB1GLRA1KCNH2LMNA | |
| SCHEMBL4598135 | 0.86 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1GLRA1KCNH2LMNA | |
| SCHEMBL20173650 | 0.79 | ALDH1A1 (0.54) | HSP90AA1HSP90AB1KCNH2LMNARECQL | |
| SCHEMBL20173647 | 0.79 | HPGD (0.54) | HSP90AA1HSP90AB1KCNH2LMNARECQL | |
| SCHEMBL20164980 | 0.78 | HPGD (0.59) | HSP90AA1HSP90AB1KCNH2ALDH1A1HPGD | |
| SCHEMBL20173649 | 0.78 | HPGD (0.57) | HSP90AA1HSP90AB1KCNH2ALDH1A1HPGD | |
| SCHEMBL20164957 | 0.76 | GLRA1 (0.64) | HSP90AA1HSP90AB1GLRA1KCNH2ALDH1A1 | |
| SCHEMBL20164958 | 0.76 | GLRA1 (0.64) | HSP90AA1HSP90AB1GLRA1KCNH2ALDH1A1 | |
| SCHEMBL4597513 | 0.75 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1KCNH2LMNARECQL | |
| SCHEMBL11613230 | 0.75 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727793-B1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2008-04-09 | — | — | EP | claimed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | claimed |
| EP-1727793-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-12-06 | — | — | EP | claimed |
| WO-2005077896-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1-CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2005-08-25 | — | — | WO | claimed |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | LABORATOIOS DE DR. ESTEVE S.A. (ES) | 2005-08-18 | — | — | US | claimed |
| EP-1727793-B1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2008-04-09 | — | — | EP | disclosed |
| US-7232812-B2 | Substituted azetidine compounds, their preparation and use as medicaments | LABORATORIOS DE DR. ESTEVE S.A. (ES) | 2007-06-19 | — | — | US | disclosed |
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A (ES) | 2007-04-26 | — | — | US | disclosed |
| EP-1727793-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1 - CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005077896-A1 | SUBSTITUTED AZETIDINE COMPOUNDS AS CYCLOOXYGENASE-1-CYCLOOXYGENASE-2 INHIBITORS, AND THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2005-08-25 | — | — | WO | disclosed |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | LABORATOIOS DE DR. ESTEVE S.A. (ES) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093469-A1 | Substituted azetidine compounds as cyclooxygenase-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments | PTGS1, PTGS2, PTGES2 | HSP90AA1 482/4885HSP90AB1 644/4885GLRA1 1022/4885 |
| US-20050182041-A1 | Substituted Azetidine compounds, their preparation and use as medicaments | AZI2, NISCH, QDPR | HSP90AA1 1727/4885HSP90AB1 1982/4885GLRA1 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.