Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301656 | 0.76 | HSD17B1 (0.37) | TDP1HSD17B1MAPT | |
| SCHEMBL2305004 | 0.76 | TYR (0.46) | ALDH1A1TDP1HSD17B1MAPTGAA | |
| SCHEMBL4447289 | 0.74 | ALDH1A1 (0.32) | ALDH1A1TDP1MAPTL3MBTL1VCAM1 | |
| SCHEMBL4458486 | 0.74 | HTR2A (0.48) | ALDH1A1HSD17B1 | |
| SCHEMBL1025369 | 0.73 | ALDH1A1 (0.40) | ALDH1A1TDP1MAPTGAABAZ1A | |
| SCHEMBL28968860 | 0.73 | ALDH1A1 (0.55) | ALDH1A1TDP1MAPTL3MBTL1VCAM1 | |
| SCHEMBL11063518 | 0.71 | VCAM1 (0.44) | ALDH1A1TDP1MAPTL3MBTL1VCAM1 | |
| SCHEMBL6204798 | 0.70 | MAPK1 (0.42) | ALDH1A1TDP1MAPTVCAM1BAZ1A | |
| SCHEMBL11980460 | 0.70 | BAZ1A (0.37) | ALDH1A1HSD17B1MAPTLMNABAZ1A | |
| SCHEMBL7894568 | 0.70 | ATM (0.42) | ALDH1A1TDP1HSD17B1MAPTVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910338-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009120-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM LLC (BM) | 2007-01-18 | — | — | WO | disclosed |