Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5424757 | 0.98 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4ENPC1LMNA | |
| SCHEMBL5499546 | 0.86 | TSHR (0.56) | ALDH1A1TSHRNPC1LMNASMN1; SMN2 | |
| SCHEMBL13126456 | 0.84 | TSHR (0.41) | ALDH1A1TSHRKDM4ENPC1LMNA | |
| SCHEMBL28036519 | 0.81 | MAPK14 (0.46) | ALDH1A1NPC1LMNAGABRPGABRD | |
| SCHEMBL27758253 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4ENPC1LMNA | |
| SCHEMBL7811465 | 0.80 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL2806923 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TSHRKDM4ENPC1LMNA | |
| SCHEMBL6052434 | 0.79 | KDM4E (0.41) | ALDH1A1TSHRKDM4ELMNASMN1; SMN2 | |
| SCHEMBL27737639 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TSHRKDM4ENPC1LMNA | |
| SCHEMBL7105351 | 0.78 | NPC1 (0.64) | ALDH1A1TSHRKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135857-A | Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole | 杭州迪克科技有限公司 | 2021-07-20 | — | — | CN | claimed |
| CN-113135857-A | Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole | 杭州迪克科技有限公司 | 2021-07-20 | — | — | CN | disclosed |
| CN-113135857-A | Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole | 杭州迪克科技有限公司 | 2021-07-20 | — | — | CN | disclosed |
| EP-2628730-B1 | TELESCOPING SYNTHESIS OF 5-AMINO-4-NITROSO-1-ALKYL-1H-PYRAZOLE SALTS | NOXELL CORP (US) | 2017-12-06 | — | — | EP | disclosed |
| CN-105294564-A | Synthetic method of 5-amino-1-(2-hydroxyethyl)pyrazole | SHANDONG BOYUAN PHARMACEUTICAL CO LTD | 2016-02-03 | — | — | CN | disclosed |
| CN-104105689-A | Synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt by telescoping | PROCTER & GAMBLE | 2014-10-15 | — | — | CN | disclosed |
| US-8785656-B2 | Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt | THE PROCTER & GAMBLE COMPANY (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130217891-A1 | Telescoping Synthesis of 5-Amino-4-Nitroso-1-Alkyl-1H-Pyrazole Salt | THE PROCTER & GAMBLE COMPANY (US) | 2013-08-22 | — | — | US | disclosed |
| EP-2628730-A1 | Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salts | The Procter and Gamble Company (US) | 2013-08-21 | — | — | EP | disclosed |
| CN-101287710-A | Preparation of 4, 5-diamino-1- (substituted) pyrazoles and their acid addition salts | EASTMAN CHEM CO (US) | 2008-10-15 | — | — | CN | disclosed |
| EP-1912950-A2 | PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007021873-A2 | PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-02-22 | — | — | WO | disclosed |
| WO-2007021873-A2 | PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY | 2007-02-15 | — | — | US | disclosed |
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY | 2007-02-15 | — | — | US | disclosed |
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY | 2007-02-15 | — | — | US | disclosed |
| EP-1342716-A2 | Preparation of 4,5-diamino-1-(2'-hydroxyethyl)-pyradazole and acid addition salts thereof | EASTMAN CHEMICAL COMPANY (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6452019-B1 | SIMPLIFIED PROCESS THAT DOES NOT INVOLVE TOXIC SOLVENTS NOR MULTIPLE ISOLATIONS OF INTERMEDIATE PRODUCTS; CYCLIZATION OF ALKYL(ETHOXYMETHYLENE)CYANOACETATE AND 2-HYDROXY-ETHYL-HYDRAZINE; DECARBOXYLATING; NITROSATION TO AMINATE | EASTMAN CHEMICAL COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-5663366-A | Process for the synthesis of 4,5-diaminopyrazole derivatives useful for dyeing hair | WELLA AKTIENGESELLSCHAT (DE) | 1997-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037987-A1 | Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof | DDC, DAO, IL4I1 | ALDH1A1 154/4885TSHR 4160/4885KDM4E 1165/4885 |
| US-20130217891-A1 | Telescoping Synthesis of 5-Amino-4-Nitroso-1-Alkyl-1H-Pyrazole Salt | NOX5, PPOX, PAOX | ALDH1A1 1135/4885TSHR 1296/4885KDM4E 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.