Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618715 | 0.87 | NOD2 (0.50) | CCR2KDM4EALDH1A1HPGDHSP90AA1 | |
| SCHEMBL15361980 | 0.80 | OPRD1 (0.44) | HSP90AA1RAB9A | |
| SCHEMBL2895007 | 0.78 | CCR2 (0.70) | CCR2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL4600229 | 0.78 | CCR2 (0.56) | CCR2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL832189 | 0.77 | CCR2 (0.71) | CCR2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL4600132 | 0.77 | CCR2 (0.61) | CCR2GPR35KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL926656 | 0.76 | CCR2 (0.70) | CCR2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL4599842 | 0.75 | CCR2 (0.59) | CCR2GPR35KDM4EALDH1A1HPGD | |
| SCHEMBL6308068 | 0.75 | CCR2 (0.73) | CCR2GPR35PTGS1PTGS2 | |
| SCHEMBL7239402 | 0.75 | CCR2 (0.69) | CCR2GPR35PTGS1PTGS2SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | claimed |
| EP-1910335-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007010144-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2007-01-25 | — | — | WO | claimed |