Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21594121 | 0.82 | — | — | |
| SCHEMBL4604377 | 0.79 | EPHX2 (0.36) | — | |
| SCHEMBL4632919 | 0.78 | — | — | |
| SCHEMBL4634051 | 0.76 | KDM4E (0.36) | — | |
| SCHEMBL24820140 | 0.76 | — | — | |
| SCHEMBL20833142 | 0.76 | LMNA (0.30) | — | |
| SCHEMBL22519401 | 0.74 | PDCD1 (0.31) | — | |
| SCHEMBL23374694 | 0.74 | LMNA (0.33) | — | |
| SCHEMBL4602173 | 0.72 | ANPEP (0.31) | — | |
| SCHEMBL10241509 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |