Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825622 | 0.81 | KMT2A (0.41) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL4598534 | 0.76 | MC4R (0.40) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28583802 | 0.73 | CYP2C19 (0.47) | CYP2C19KCNA5GAAMEN1KMT2A | |
| SCHEMBL23354438 | 0.72 | ALDH1A1 (0.45) | GAAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26906885 | 0.72 | ALDH1A1 (0.45) | GAAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6466556 | 0.71 | MTNR1A (0.44) | MEN1KMT2ANPSR1 | |
| SCHEMBL6342824 | 0.70 | KCNA3 (0.42) | KCNA5MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL4600703 | 0.70 | HDAC6 (0.48) | KMT2ASMN1; SMN2TSHRLMNACYP3A4 | |
| SCHEMBL14737238 | 0.69 | MMP9 (0.42) | CYP2C19MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL30771400 | 0.68 | MEN1 (0.46) | CYP2C19GAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |