Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ATP4A | P20648 | 2/20 | 0.32 |
| ▸ | ATP4B | P51164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600268 | 0.92 | ALDH1A1 (0.34) | KDM4EALDH1A1ATP4AATP4B | |
| SCHEMBL4599487 | 0.91 | L3MBTL1 (0.33) | KDM4EALDH1A1ATP4AATP4B | |
| SCHEMBL4600936 | 0.91 | JAK2 (0.34) | JAK2JAK1KDM4EALDH1A1ATP4A | |
| SCHEMBL4600463 | 0.90 | ALDH1A1 (0.35) | JAK2JAK1KDM4EALDH1A1ATP4A | |
| SCHEMBL4600263 | 0.82 | ALDH1A1 (0.35) | KDM4EALDH1A1ATP4AATP4B | |
| SCHEMBL4600269 | 0.82 | ALDH1A1 (0.35) | KDM4EALDH1A1ATP4AATP4B | |
| SCHEMBL4599488 | 0.82 | MAPT (0.35) | KDM4EALDH1A1ATP4AATP4BPOLB | |
| SCHEMBL4599481 | 0.82 | MAPT (0.35) | KDM4EALDH1A1ATP4AATP4BPOLB | |
| SCHEMBL4600457 | 0.81 | ALDH1A1 (0.36) | JAK2JAK1KDM4EALDH1A1ATP4A | |
| SCHEMBL4600465 | 0.81 | ALDH1A1 (0.36) | JAK2JAK1KDM4EALDH1A1ATP4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1718648-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | Altana Pharma AG (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077949-A1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | ALTANA PHARMA AG (DE) | 2005-08-25 | — | — | WO | disclosed |