Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 5/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 2/20 | 0.33 |
| ▸ | FNTB | P49356 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600646 | 0.91 | SCN9A (0.41) | ALOX5APFEN1ANO1SCN9ASMN1; SMN2 | |
| SCHEMBL4632372 | 0.90 | SCN9A (0.35) | ALOX5APFEN1ANO1SCN9ASMN1; SMN2 | |
| SCHEMBL4602360 | 0.90 | ANO1 (0.41) | ANO1AURKBSCN9ASMN1; SMN2FNTA | |
| SCHEMBL4601576 | 0.88 | CTSS (0.42) | ALOX5APFEN1ANO1SCN9ASMN1; SMN2 | |
| SCHEMBL4632696 | 0.80 | CTSS (0.44) | SCN9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL267770 | 0.79 | SCN9A (0.40) | ALOX5APFEN1ANO1SCN9A | |
| SCHEMBL268189 | 0.77 | ALOX5AP (0.37) | ALOX5APFEN1ANO1RXFP1SCN9A | |
| SCHEMBL4602131 | 0.77 | KCNA5 (0.40) | SMN1; SMN2 | |
| SCHEMBL4837234 | 0.76 | ANO1 (0.39) | ANO1SMN1; SMN2 | |
| SCHEMBL4600309 | 0.75 | SCN9A (0.43) | ANO1AURKBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |