Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600174 | 0.85 | KCNA5 (0.39) | KCNA5KCNK3KCNA3SMN1; SMN2KDR | |
| SCHEMBL4600172 | 0.85 | KCNA5 (0.39) | KCNA5KCNK3KCNA3SMN1; SMN2KDR | |
| SCHEMBL4601576 | 0.80 | CTSS (0.42) | KCNA5SMN1; SMN2L3MBTL1TSHRRAB9A | |
| SCHEMBL4600646 | 0.79 | SCN9A (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL269619 | 0.79 | ITGB3 (0.39) | KCNA5 | |
| SCHEMBL4632372 | 0.79 | SCN9A (0.35) | SMN1; SMN2KDRLMNA | |
| SCHEMBL4602360 | 0.79 | ANO1 (0.41) | SMN1; SMN2 | |
| SCHEMBL4600968 | 0.77 | ALOX5AP (0.37) | SMN1; SMN2 | |
| SCHEMBL268081 | 0.77 | TRPM8 (0.38) | KCNA5SMN1; SMN2L3MBTL1TSHRCASP3 | |
| SCHEMBL268080 | 0.77 | TRPM8 (0.38) | KCNA5SMN1; SMN2L3MBTL1TSHRCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |