Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602508 | 0.88 | PDE4A (0.40) | SMN1; SMN2MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL4601061 | 0.87 | POLB (0.39) | SCN9ARAB9AMAPTNPC1CNR2 | |
| SCHEMBL4601672 | 0.74 | SMN1; SMN2 (0.41) | SCN9ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL3218749 | 0.73 | PPARG (0.39) | SCN9ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL4601426 | 0.73 | RAB9A (0.39) | SCN9ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL4601015 | 0.72 | BCHE (0.36) | TSHRLMNA | |
| SCHEMBL4600575 | 0.68 | PPARG (0.40) | SCN9A | |
| SCHEMBL27716314 | 0.67 | MAPT (0.42) | SCN9ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL27716267 | 0.65 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2MAPTNPC1CNR2 | |
| SCHEMBL4601910 | 0.65 | PPARG (0.45) | SMN1; SMN2ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |