Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.42 |
| ▸ | ITK | Q08881 | 7/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602781 | 0.82 | EGFR (0.45) | EGFRITKBTKJAK2LYN | |
| SCHEMBL4602178 | 0.82 | EGFR (0.43) | EGFRITKBTKJAK2LYN | |
| SCHEMBL4601414 | 0.75 | EGFR (0.44) | EGFRITK | |
| SCHEMBL30843868 | 0.74 | NAMPT (0.40) | EGFRRORCSYKNAMPT | |
| SCHEMBL29157693 | 0.74 | NAMPT (0.40) | EGFRRORCSYKNAMPT | |
| SCHEMBL3196875 | 0.73 | PPARG (0.43) | EGFRITK | |
| SCHEMBL4600789 | 0.73 | HPGD (0.48) | — | |
| SCHEMBL14923668 | 0.70 | SYK (0.42) | EGFRITKRORCSYKNAMPT | |
| SCHEMBL4614803 | 0.69 | EGFR (0.42) | EGFRITK | |
| SCHEMBL4600628 | 0.69 | EGFR (0.47) | EGFRITKBTKJAK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |