Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | THRB | P10828 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | TEC | P42680 | 1/20 | 0.33 |
| ▸ | TXK | P42681 | 1/20 | 0.33 |
| ▸ | BMX | P51813 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CD69 | Q07108 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600425 | 0.85 | MAPT (0.46) | EGFRGAAL3MBTL1LMNAMAPT | |
| SCHEMBL4600130 | 0.83 | EGFR (0.47) | EGFRTHRBKDM4ELMNAMEN1 | |
| SCHEMBL4602781 | 0.81 | EGFR (0.45) | EGFRKDM4EMEN1KMT2ABTK | |
| SCHEMBL4601601 | 0.79 | EGFR (0.47) | EGFRTHRBGAAKDM4ELMNA | |
| SCHEMBL4602183 | 0.78 | EGFR (0.47) | EGFRTHRBGAAL3MBTL1MAPT | |
| SCHEMBL4601033 | 0.77 | EGFR (0.44) | EGFRTHRBKDM4ETHRA | |
| SCHEMBL4614803 | 0.75 | EGFR (0.42) | EGFRTHRBTHRAITK | |
| SCHEMBL4601414 | 0.75 | EGFR (0.44) | EGFRL3MBTL1KDM4ELMNAITK | |
| SCHEMBL4602178 | 0.75 | EGFR (0.43) | EGFRKDM4ELMNAMEN1KMT2A | |
| SCHEMBL4602169 | 0.75 | EGFR (0.41) | EGFRKDM4EKMT2AITKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |