Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 11/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632009 | 0.87 | CHRNB2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4ACHE | |
| SCHEMBL4603603 | 0.80 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4ACHE | |
| SCHEMBL28522595 | 0.73 | ACHE (0.56) | ACHENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL11465997 | 0.72 | MAPT (0.61) | LMNAMAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL29024707 | 0.72 | DGKA (0.51) | LMNAMAPTALDH1A1 | |
| SCHEMBL29024902 | 0.72 | DGKA (0.51) | LMNAMAPTALDH1A1 | |
| SCHEMBL29024901 | 0.72 | DGKA (0.51) | LMNAMAPTALDH1A1 | |
| SCHEMBL29024897 | 0.72 | DGKA (0.51) | LMNAMAPTALDH1A1 | |
| SCHEMBL29024898 | 0.72 | DGKA (0.51) | LMNAMAPTALDH1A1 | |
| SCHEMBL1866206 | 0.71 | MAPT (0.64) | LMNAMAPTALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915351-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007011618-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |