Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 14/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4601994 | 0.87 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4ACHE | |
| SCHEMBL4602214 | 0.78 | EPHX1 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4ACHE | |
| SCHEMBL4696577 | 0.75 | ACHE (0.62) | ACHE | |
| SCHEMBL1696820 | 0.73 | ACHE (0.66) | ACHE | |
| SCHEMBL29024897 | 0.73 | DGKA (0.51) | LMNA | |
| SCHEMBL29024901 | 0.73 | DGKA (0.51) | LMNA | |
| SCHEMBL29024898 | 0.73 | DGKA (0.51) | LMNA | |
| SCHEMBL29024902 | 0.73 | DGKA (0.51) | LMNA | |
| SCHEMBL29024707 | 0.73 | DGKA (0.51) | LMNA | |
| SCHEMBL5496557 | 0.73 | EPHX1 (0.41) | ACHENPC1RAB9ASMN1; SMN2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924568-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007011623-A1 | QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT | SCHERING CORPORATION (US) | 2007-01-25 | — | — | WO | disclosed |