Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21814302 | 0.94 | NAMPT (0.59) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL21814278 | 0.93 | NAMPT (0.61) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL21814291 | 0.90 | NAMPT (0.54) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL21814300 | 0.90 | HRH3 (0.51) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL241165 | 0.85 | SRD5A1 (0.62) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL213590 | 0.84 | SRD5A1 (0.50) | LMNAKMT2AHRH3 | |
| SCHEMBL14413530 | 0.84 | PARP10 (0.50) | POLBKMT2AHRH3 | |
| SCHEMBL9013886 | 0.83 | CASP6 (0.53) | MAPTNAMPTKMT2AHRH3 | |
| SCHEMBL24884425 | 0.81 | NAMPT (0.57) | LMNAMAPTKDM4EL3MBTL1POLB | |
| SCHEMBL241369 | 0.81 | L3MBTL1 (0.61) | LMNAMAPTKDM4EL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1609789-A1 | UREIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-12-28 | — | — | EP | disclosed |