SCHEMBL4603853

SCHEMBL4603853

OC1(O)C=CC(c2cccc(Cl)c2)C=C1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
MCL1 Q07820 1/20 0.37
HTR2A P28223 2/20 0.35
HTR2C P28335 2/20 0.35
HTR2B P41595 2/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
KDM1A O60341 1/20 0.35
RCOR1 Q9UKL0 1/20 0.35
TSHR P16473 2/20 0.34
SLC9A1 P19634 2/20 0.34
TRPM4 Q8TD43 1/20 0.34
TRPM5 Q9NZQ8 1/20 0.34
SLC6A3 Q01959 2/20 0.33
TAAR1 Q96RJ0 1/20 0.33
SLC6A2 P23975 1/20 0.33
HTT P42858 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1628429 0.80 KDM1A (0.41) MEN1KMT2AMCL1HTR2AHTR2C
SCHEMBL8520712 0.73 SLC9A1 (0.33) MEN1KMT2AMCL1HTR2AHTR2C
SCHEMBL10410658 0.69 ALDH1A1 (0.39) HTR2AHTR2CHTR2BMAPTKDM1A
SCHEMBL5025393 0.69 CYP2C19 (0.34) HTR2AHTR2CHTR2BKDM1ARCOR1
SCHEMBL2165693 0.69 KMT2A (0.36) MEN1KMT2AHTR2AHTR2CHTR2B
Hydrochloric Acid SCHEMBL10800689 0.68 CYP3A4 (0.33) ALDH1A1
SCHEMBL28427463 0.66 SLC6A3 (0.38) HTR2AHTR2CHTR2BKDM1ARCOR1
SCHEMBL8500794 0.65 KMT2A (0.39) MEN1KMT2ASLC9A1ALDH1A1
SCHEMBL18663398 0.65 KMO (0.43) HPGD
SCHEMBL15327483 0.64 TAAR1 (0.44) MEN1KMT2AMCL1HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940913-A2 METHODS FOR PREPARING TRANSPARENT ARTICLES FROM BIPHENOL POLYCARBONATE COPOLYMERS General Electric Company (US) 2008-07-09 EP disclosed
WO-2007053327-A2 METHODS FOR PREPARING TRANSPARENT ARTICLES FROM BIPHENOL POLYCARBONATE COPOLYMERS GENERAL ELECTRIC COMPANY (US) 2007-05-10 WO disclosed
US-6323302-B1 SUPPLYING AROMATIC DIHYDROXY COMPOUND POWDER AND A CARBONIC ACID DIESTER INTO MELTING VESSEL THROUGH A TRANSPORTATION PIPING; MIXING MELTING; INITIATING MELT POLYMERIZATION IN PRESENCE OR ABSENCE OF CATALYST TEIJIN LIMITED (JP) 2001-11-27 US disclosed
EP-0700532-B1 ALIGNMENT LAYER FOR LIQUID CRYSTALS AVENTIS RES & TECH GMBH & CO (DE) 2000-03-29 EP disclosed
US-5744203-A POLYMER MIXTURES OF POLYURETHANES, POLYESTERS, POLYIMIDES, POLYCARBONATES AND POLYUREAS HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed
EP-0708149-A1 Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-24 EP disclosed
EP-0700532-A1 ALIGNMENT LAYER FOR LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1996-03-13 EP disclosed
WO-1994028458-A1 ALIGNMENT LAYER FOR LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-12-08 WO disclosed
US-4983648-A Molded objects; polycarbonate and/or aromatic polyester carbonate, additive, rubbery polymer as concentrate resin; let-down resin for dispersing concentrate resin; melt combining in molding machine THE DOW CHEMICAL COMPANY (US) 1991-01-08 US disclosed
US-4349658-A Flame retardant aromatic polyester-carbonate copolymer compositions GENERAL ELECTRIC COMPANY (US) 1982-09-14 US disclosed
WO-1982002401-A1 BLENDS OF COPOLYESTER-CARBONATE WITH POLYSULFONE GEN ELECTRIC (US) 1982-07-22 WO disclosed
WO-1982002389-A1 BENZOATE ESTER TERMINATED POLYCARBONATE GEN ELECTRIC (US) 1982-07-22 WO disclosed
WO-1982002390-A1 FLAME RETARDANT AROMATIC POLYESTER-CARBONATE COPOLYMER COMPOSITIONS GEN ELECTRIC (US) 1982-07-22 WO disclosed
US-4335039-A DIOXANE PHOSPHITE STABILIZER GENERAL ELECTRIC COMPANY (US) 1982-06-15 US disclosed
US-4276233-A THERMAL STABILIZERS FOR POLYCARBONATES GENERAL ELECTRIC COMPANY (US) 1981-06-30 US disclosed
US-4247448-A POLYVINYL CHLORIDE, POLYESTERS, POLYOLEFINS GENERAL ELECTRIC COMPANY (US) 1981-01-27 US disclosed
US-4240968-A CONCENTRATION OF CHROMAN I FROM A SLURRY GENERAL ELECTRIC COMPANY (US) 1980-12-23 US disclosed
US-4238597-A Process for producing copolyester-carbonates GENERAL ELECTRIC COMPANY (US) 1980-12-09 US disclosed
US-4238596-A Process for obtaining copolyester-carbonates GENERAL ELECTRIC COMPANY (US) 1980-12-09 US disclosed